MAML3 Antikörper

Produktnummer ABIN6295979

Der Maus-Monoklonal Anti-MAML3-Antikörper wurde für FACS, IF und IHC validiert. Er ist geeignet zum Nachweis von MAML3 in Proben aus Human. }

Kurzübersicht für MAML3 Antikörper (ABIN6295979)

Target: MAML3 (Mastermind-Like 3 (MAML3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAML3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-MAML3 Antikörper

Verwendungszweck: Mouse anti-Human MAML3 Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: A human full length recombinant protein was used as the immunogen for this MAML3 antibody.

Immunogen: A human full length recombinant protein was used as the immunogen for this MAML3 antibody.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu MAML3

Target: MAML3 (Mastermind-Like 3 (MAML3))

Andere Bezeichnung: Mastermind-like protein 3

Hintergrund:

Target Description: Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.

Gene Symbol: MAML3///KIAA1816

Gen-ID: 55534

UniProt: Q96JK9