KRT8 Antikörper

Produktnummer ABIN6295952

Der Maus Monoklonal anti-KRT8 Antikörper wird verwendet zum Nachweis von KRT8 in Proben von Human, Ratte und Zebrafisch (Danio rerio). Er wurde validiert für IHC, IF und FACS.

Kurzübersicht für KRT8 Antikörper (ABIN6295952)

Target: KRT8 (Keratin 8 (KRT8))

Reaktivität: Human, Ratte, Zebrafisch (Danio rerio)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KRT8 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-KRT8 Antikörper

Verwendungszweck: Mouse anti-Human/Rat/Zebrafish Cytokeratin 8 Antibody Cocktail [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: A cytoskeleton preparation containing Cytokeratin 8 (H1) and Keratin preparation from a human carcinoma (TS1) were used as the immunogen for this antibody cocktail.

Immunogen: A cytoskeleton preparation containing Cytokeratin 8 (H1) and Keratin preparation from a human carcinoma (TS1) were used as the immunogen for this antibody cocktail.

Anwendungsinformationen

Applikationshinweise: FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1.0 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu KRT8

Target: KRT8 (Keratin 8 (KRT8))

Andere Bezeichnung: Keratin, type II cytoskeletal 8

Hintergrund:

Target Description: Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibody that recognizes only cytokeratin 8 and 18. Cytokeratin 8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. antibody to Cytokeratin 8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against Cytokeratin 8, 18 and 19). Reportedly, Cytokeratin 8 antibody is useful for the differentiation of lobular ( ""ring-like, perinuclear "") from ductal ( ""peripheral-predominant "") carcinoma of the breast.

Gene Symbol: KRT8///CYK8

Gen-ID: 3856

UniProt: P05787