PTH Antikörper (N-Term)

Produktnummer ABIN6295481

Der Kaninchen Polyklonal anti-PTH Antikörper wird verwendet zum Nachweis von PTH in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für PTH Antikörper (N-Term) (ABIN6295481)

Target: PTH (Parathyroid Hormone (PTH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTH Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-PTH Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Rabbit anti-Human Recombinant Parathyroid Hormone Antibody (N-Terminal) [IHC only]

Spezifität: Cytoplasmic and secreted

Aufreinigung: A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the recombinant PTH antibody.

Immunogen: A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the recombinant PTH antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted IHC only format: incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu PTH

Target: PTH (Parathyroid Hormone (PTH))

Andere Bezeichnung: Parathyroid hormone

Substanzklasse: Hormone

Hintergrund:

Target Description: PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Gene Symbol: PTH

Gen-ID: 5741

UniProt: P01270

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process