FBXO5 Antikörper (N-Term)

Produktnummer ABIN6295467

Dieses Anti-FBXO5-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von FBXO5 in IHC. Geeignet für Human.

Kurzübersicht für FBXO5 Antikörper (N-Term) (ABIN6295467)

Target: FBXO5 (F-Box Protein 5 (FBXO5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FBXO5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-FBXO5 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Mouse anti-Human EMI-1 Antibody [IHC only]

Spezifität: Nuclear

Aufreinigung: A human partial recombinant N-terminal protein fragment was used as the immunogen for the EMI-1 antibody.

Immunogen: A human partial recombinant N-terminal protein fragment was used as the immunogen for the EMI-1 antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu FBXO5

Target: FBXO5 (F-Box Protein 5 (FBXO5))

Andere Bezeichnung: F-box only protein 5

Hintergrund:

Target Description: Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

Gene Symbol: FBXO5///EMI1///FBX5

Gen-ID: 26271

UniProt: Q9UKT4

Pathways: Mitotic G1-G1/S Phases