TFF1 Antikörper (C-Term)

Produktnummer ABIN6294640

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TFF1 in IHC, IF und FACS. Er zeigt eine Reaktivität gegenüber Human und Affe.

Kurzübersicht für TFF1 Antikörper (C-Term) (ABIN6294640)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TFF1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-TFF1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Mouse anti-Human/Monkey TFF1 Antibody [Sodium Azide Free]

Spezifität: Cytoplasmic

Aufreinigung: A C-terminus peptide was used as the immunogen for the TFF1 antibody.

Immunogen: A C-terminus peptide was used as the immunogen for the TFF1 antibody.

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Andere Bezeichnung: Trefoil factor 1

Hintergrund:

Target Description: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

Gene Symbol: TFF1///BCEI///PS2

Gen-ID: 7031

UniProt: P04155

Pathways: EGFR Signaling Pathway