Isocitrate Dehydrogenase [NADP],cytoplasmic (IDH2) (AA 280-420) Antikörper

Produktnummer ABIN6294441

Der Maus Monoklonal anti-Isocitrate Dehydrogenase [NADP],cytoplasmic Antikörper (ABIN6294441) detektiert spezifisch Isocitrate Dehydrogenase [NADP],cytoplasmic in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Isocitrate Dehydrogenase [NADP],cytoplasmic (IDH2) (AA 280-420) Antikörper (ABIN6294441)

Target: Isocitrate Dehydrogenase [NADP],cytoplasmic (IDH2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails

Bindungsspezifität: AA 280-420

Verwendungszweck: Mouse anti-Human IDH1 Antibody [IHC only]

Spezifität: Cytoplasmic & nuclear

Aufreinigung: A recombinant fragment (119 amino acid residues around aa 280-420) from the human protein was used as the immunogen for the IDH1 antibody.

Immunogen: A recombinant fragment (119 amino acid residues around aa 280-420) from the human protein was used as the immunogen for the IDH1 antibody.

Anwendungsinformationen

Applikationshinweise: Prediluted format : incubate for 30 min at RT (2)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Antigendetails

Target: Isocitrate Dehydrogenase [NADP],cytoplasmic (IDH2)

Andere Bezeichnung: Isocitrate dehydrogenase cytoplasmic

Hintergrund:

Target Description: It recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming a-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of a-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

Gene Symbol: IDH1///PICD

Gen-ID: 3417

UniProt: O75874