FLI1 Antikörper (AA 107-216)

Produktnummer ABIN6294274

Dieses Maus Monoklonal-Antikörper erkennt spezifisch FLI1 in WB, IF und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FLI1 Antikörper (AA 107-216) (ABIN6294274)

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FLI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktdetails anti-FLI1 Antikörper

Bindungsspezifität: AA 107-216

Verwendungszweck: Mouse anti-Human FLI1 Antibody [Sodium Azide Free]

Spezifität: Nuclear

Aufreinigung: Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.

Immunogen: Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.

Anwendungsinformationen

Applikationshinweise: Western blot: 1-2 μg/m,l
FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Details zu FLI1

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Andere Bezeichnung: Friend leukemia integration 1 transcription factor

Hintergrund:

Target Description: Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90 % of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11,22)(q24,q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.

Gene Symbol: FLI1

Gen-ID: 2313

UniProt: Q01543