ZBTB17 Antikörper (Internal Region)

Produktnummer ABIN6266089

Dieses Anti-ZBTB17-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ZBTB17 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ZBTB17 Antikörper (Internal Region) (ABIN6266089)

Target: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZBTB17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ZBTB17 Antikörper

Bindungsspezifität: Internal Region

Spezifität: ZBTB17 Antibody detects endogenous levels of total ZBTB17.

Homologie: Pig,Bovine,Horse,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZBTB17, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ZBTB17

Target: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Andere Bezeichnung: ZBTB17

Hintergrund:

Description: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription, this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

Gene: ZBTB17

Molekulargewicht: 88 kDa

Gen-ID: 7709

UniProt: Q13105

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, ER-Nucleus Signaling