XRN2 Antikörper

Produktnummer ABIN6266072

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch XRN2 in WB, ELISA, IHC, ICC und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Affe.

Kurzübersicht für XRN2 Antikörper (ABIN6266072)

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Reaktivität: Human, Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XRN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-XRN2 Antikörper

Spezifität: XRN2 Antibody detects endogenous levels of XRN2

Kreuzreaktivität: Human, Affe, Maus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human XRN2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu XRN2

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Andere Bezeichnung: XRN2

Hintergrund:

Description: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).

Gene: XRN2

Molekulargewicht: 108kDa

Gen-ID: 22803

UniProt: Q9H0D6