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VPS11 Antikörper (Internal Region)

VPS11 Reaktivität: Human, Maus, Ratte WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6265995
  • Target Alle VPS11 Antikörper anzeigen
    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))
    Bindungsspezifität
    • 8
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 31
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 27
    • 3
    • 1
    Kaninchen
    Klonalität
    • 28
    • 3
    Polyklonal
    Konjugat
    • 21
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser VPS11 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 19
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    VPS11 Antibody detects endogenous levels of total VPS11.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human VPS11, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product VPS11 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))
    Andere Bezeichnung
    VPS11 (VPS11 Produkte)
    Synonyme
    zgc:112329 antikoerper, ATVPS11 antikoerper, F5G3.7 antikoerper, F5G3_7 antikoerper, vacuolar protein sorting 11 antikoerper, DDBDRAFT_0204454 antikoerper, DDBDRAFT_0234135 antikoerper, DDB_0204454 antikoerper, DDB_0234135 antikoerper, end1 antikoerper, pep5 antikoerper, hvps11 antikoerper, rnf108 antikoerper, 1200011A11Rik antikoerper, END1 antikoerper, PEP5 antikoerper, RNF108 antikoerper, hVPS11 antikoerper, VPS11, CORVET/HOPS core subunit antikoerper, vacuolar protein sorting 11 antikoerper, vacuolar protein sorting protein 11 antikoerper, VPS11, CORVET/HOPS core subunit S homeolog antikoerper, Vacuolar peripheral membrane protein similar to S. cerevisiae PEP5 (YMR231W); C terminus is almost identical to nonallelic CaP19.1278 antikoerper, 7-fold repeat in clathrin and VPS proteins repeat-containing protein antikoerper, vacuolar protein sorting-associated protein 11 homolog antikoerper, VPS11 CORVET/HOPS core subunit antikoerper, VPS11 antikoerper, vps11 antikoerper, MCYG_02909 antikoerper, vps11.S antikoerper, LOC100632536 antikoerper, Vps11 antikoerper
    Hintergrund

    Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

    Gene: VPS11

    Molekulargewicht
    108-112 kDa
    Gen-ID
    55823
    UniProt
    Q9H270
    Pathways
    SARS-CoV-2 Protein Interaktom
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