USP9X Antikörper (N-Term)

Produktnummer ABIN6265937

Produktdetails anti-USP9X Antikörper

Target: USP9X (Ubiquitin Specific Peptidase 9, X-Linked (USP9X))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP9X Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: USP9X Antibody detects endogenous levels of total USP9X.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP9X, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu USP9X

Target: USP9X (Ubiquitin Specific Peptidase 9, X-Linked (USP9X))

Andere Bezeichnung: USP9X (USP9X Produkte)

Synonyme: DFFRX antikoerper, FAF antikoerper, FAM antikoerper, RGD1560056 antikoerper, faf antikoerper, fam antikoerper, dffrx antikoerper, 5730589N07Rik antikoerper, AA407302 antikoerper, AA407699 antikoerper, AL022658 antikoerper, AL022749 antikoerper, Dffrx antikoerper, FAF-X antikoerper, Fafl antikoerper, ubiquitin specific peptidase 9, X-linked antikoerper, ubiquitin specific peptidase 9, X chromosome antikoerper, USP9X antikoerper, Usp9x antikoerper, usp9x antikoerper

Hintergrund:

Description: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389).

Gene: USP9X

Molekulargewicht: 260-290 kDa

Gen-ID: 8239

UniProt: Q93008