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THO Complex 5 Antikörper (Internal Region)

Dieses Anti-THO Complex 5-Antikörper ist ein Rabbit Polyclonal-Antikörper zur Detektion von THO Complex 5 in ELISA, WB, IF, ICC. Geeignet für Human.
Produktnummer ABIN6265558

Kurzübersicht für THO Complex 5 Antikörper (Internal Region) (ABIN6265558)

Target

Alle THO Complex 5 (THOC5) Antikörper anzeigen
THO Complex 5 (THOC5)

Reaktivität

  • 26
  • 8
  • 7
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 25
  • 1
Kaninchen

Klonalität

  • 26
Polyklonal

Konjugat

  • 16
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser THO Complex 5 Antikörper ist unkonjugiert

Applikation

  • 13
  • 9
  • 8
  • 5
  • 3
  • 3
  • 1
ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    Spezifität

    THOC5 Antibody detects endogenous levels of total THOC5.

    Homologie

    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human THOC5, corresponding to a region within the internal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    THO Complex 5 (THOC5)

    Andere Bezeichnung

    THOC5

    Hintergrund

    Description: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes.

    Gene: THOC5

    Molekulargewicht

    79 kDa

    Gen-ID

    8563

    UniProt

    Q13769
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