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SUN2 Antikörper (Internal Region)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SUN2 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN6265376

Kurzübersicht für SUN2 Antikörper (Internal Region) (ABIN6265376)

Target

Alle SUN2 Antikörper anzeigen
SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

Reaktivität

  • 34
  • 17
  • 15
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
Human, Ratte, Maus

Wirt

  • 34
Kaninchen

Klonalität

  • 24
  • 10
Polyklonal

Konjugat

  • 19
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser SUN2 Antikörper ist unkonjugiert

Applikation

  • 23
  • 12
  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    Spezifität

    SUN2 Antibody detects endogenous levels of total SUN2.

    Homologie

    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human SUN2, corresponding to a region within the internal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    SUN2 (Sad1 and UNC84 Domain Containing 2 (SUN2))

    Andere Bezeichnung

    SUN2

    Hintergrund

    Description: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins, SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis, SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

    Gene: SUN2

    Molekulargewicht

    80 kDa.

    Gen-ID

    25777

    UniProt

    Q9UH99

    Pathways

    Maintenance of Protein Location, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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