PTTG1 Antikörper (Internal Region)

Produktnummer ABIN6264528

Produktdetails anti-PTTG1 Antikörper

Target: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTTG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PTTG1 Antibody detects endogenous levels of total PTTG1.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PTTG1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000, IF/ICC: 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PTTG1

Target: PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))

Andere Bezeichnung: PTTG1 (PTTG1 Produkte)

Synonyme: EAP1 antikoerper, HPTTG antikoerper, PTTG antikoerper, TUTR1 antikoerper, PTTG1 antikoerper, securin antikoerper, AW555095 antikoerper, C87862 antikoerper, Pttg antikoerper, Pttg3 antikoerper, Securin antikoerper, Protein Cut2 antikoerper, pituitary tumor-transforming 1 antikoerper, pituitary tumor-transforming gene 1 antikoerper, securin, sister chromatid separation inhibitor antikoerper, PTTG1 antikoerper, Pttg1 antikoerper, cut2 antikoerper

Hintergrund:

Description: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Gene: PTTG1

Molekulargewicht: 30kDa

Gen-ID: 9232

UniProt: O95997