PAWR Antikörper (C-Term)

Produktnummer ABIN6264442

Dieses Anti-PAWR-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PAWR in WB, IHC, ELISA, IF und ICC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PAWR Antikörper (C-Term) (ABIN6264442)

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAWR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-PAWR Antikörper

Bindungsspezifität: C-Term

Spezifität: PAR4 Antibody detects endogenous levels of total PAR4.

Homologie: Pig,Zebrafish,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PAR4, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Andere Bezeichnung: PAWR

Hintergrund:

Description: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Gene: PAWR

Molekulargewicht: 37 kDa

Gen-ID: 5074

UniProt: Q96IZ0