PIF1 Antikörper (Internal Region)

Produktnummer ABIN6264201

Produktdetails anti-PIF1 Antikörper

Target: PIF1 (PIF1 5'-To-3' DNA Helicase (PIF1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIF1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: PIF1 Antibody detects endogenous levels of total PIF1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PIF1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PIF1

Target: PIF1 (PIF1 5'-To-3' DNA Helicase (PIF1))

Andere Bezeichnung: PIF1 (PIF1 Produkte)

Synonyme: C15orf20 antikoerper, PIF antikoerper, 4631410M14 antikoerper, AI449441 antikoerper, cb934 antikoerper, fe11d03 antikoerper, wu:fe11d03 antikoerper, zgc:56161 antikoerper, PIF1 5'-to-3' DNA helicase antikoerper, PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) antikoerper, PIF1 antikoerper, Pif1 antikoerper, pif1.L antikoerper, pif1 antikoerper

Hintergrund:

Description: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.

Gene: PIF1

Molekulargewicht: 70 kDa

Gen-ID: 80119

UniProt: Q9H611