Nth Endonuclease III-Like 1 (NTHL1) (Internal Region) Antikörper

Produktnummer ABIN6263755

Der Kaninchen Polyklonal anti-Nth Endonuclease III-Like 1 Antikörper (ABIN6263755) detektiert spezifisch Nth Endonuclease III-Like 1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Affe.

Kurzübersicht für Nth Endonuclease III-Like 1 (NTHL1) (Internal Region) Antikörper (ABIN6263755)

Target: Nth Endonuclease III-Like 1 (NTHL1)

Reaktivität: Human, Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails

Bindungsspezifität: Internal Region

Verwendungszweck: NTHL1 Antibody

Spezifität: NTHL1 Antibody detects endogenous levels of total NTHL1

Homologie: Pig,Zebrafish,Bovine,Horse,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NTHL1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Antigendetails

Target: Nth Endonuclease III-Like 1 (NTHL1)

Andere Bezeichnung: NTHL1

Hintergrund:

Description: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Gene: NTHL1

Molekulargewicht: 34 kDa

Gen-ID: 4913

UniProt: P78549