NEURL Antikörper (Internal Region)

Produktnummer ABIN6263606

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NEURL in WB, ELISA, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NEURL Antikörper (Internal Region) (ABIN6263606)

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEURL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-NEURL Antikörper

Bindungsspezifität: Internal Region

Spezifität: Neuralized-1 Antibody detects endogenous levels of total Neuralized-1.

Homologie: Pig,Bovine,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Neuralized-1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NEURL

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Andere Bezeichnung: NEURL1

Hintergrund:

Description: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor, inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Gene: NEURL1

Molekulargewicht: 62kDa

Gen-ID: 9148

UniProt: O76050

Pathways: Notch Signalweg, EGFR Signaling Pathway