MAP4K6 Antikörper (Internal Region)
-
- Target Alle MAP4K6 (MINK1) Antikörper anzeigen
- MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))
-
Bindungsspezifität
- Internal Region
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser MAP4K6 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- MINK1 Antibody detects endogenous levels of total MINK1.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Dog,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human MINK1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product MINK1 Primärantikörper
-
-
- Applikationshinweise
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
-
- Target
- MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))
- Andere Bezeichnung
- MINK1 (MINK1 Produkte)
- Hintergrund
-
Description: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Gene: MINK1
- Molekulargewicht
- 150kDa
- Gen-ID
- 50488
- UniProt
- Q8N4C8
- Pathways
- Synaptic Membrane
-