Merlin Antikörper (C-Term)
Kurzübersicht für Merlin Antikörper (C-Term) (ABIN6263224)
Target
Alle Merlin (NF2) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Spezifität
- NF2 / Merlin Antibody detects endogenous levels of total NF2 / Merlin.
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Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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Immunogen
- A synthesized peptide derived from human NF2 / Merlin, corresponding to a region within C-terminal amino acids.
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Isotyp
- IgG
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anti-Neurofibromin 2 (NF2) (AA 477-576) antibody
NF2 Reaktivität: Human WB, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-239) antibodyNF2 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 30-311) antibodyNF2 Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 230-414) antibodyNF2 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 Reaktivität: Human WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (pSer518) antibodyNF2 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 65-95), (N-Term) antibodyNF2 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB19187 unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-507) antibodyNF2 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (AA 1-50), (pSer10) antibodyNF2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Neurofibromin 2 (NF2) (C-Term) antibodyNF2 Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
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Haltbarkeit
- 12 months
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- Merlin (NF2) (Neurofibromin 2 (NF2))
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Andere Bezeichnung
- NF2
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Hintergrund
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Description: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Gene: NF2
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Molekulargewicht
- 70kDa
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Gen-ID
- 4771
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UniProt
- P35240
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Pathways
- Cell-Cell Junction Organization
Target
-
