MAFB Antikörper (C-Term)

Produktnummer ABIN6263052

Produktdetails anti-MAFB Antikörper

Target: MAFB (Transcription Factor MafB (MAFB))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAFB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: MAFB Antibody detects endogenous levels of total MAFB.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MAFB, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu MAFB

Target: MAFB (Transcription Factor MafB (MAFB))

Andere Bezeichnung: MAFB (MAFB Produkte)

Synonyme: MAFB antikoerper, krml antikoerper, Maf-B antikoerper, XMafB antikoerper, kreisler antikoerper, MGC108453 antikoerper, valentino antikoerper, KRML antikoerper, MCTO antikoerper, Krml antikoerper, b-maf antikoerper, kr antikoerper, mafb antikoerper, val antikoerper, wu:fc22d11 antikoerper, wu:fj82a09 antikoerper, Kreisler antikoerper, Krml1 antikoerper, MAF bZIP transcription factor B antikoerper, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B antikoerper, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B S homeolog antikoerper, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba antikoerper, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) antikoerper, MAFB antikoerper, mafb antikoerper, mafb.S antikoerper, Mafb antikoerper, mafba antikoerper

Hintergrund:

Description: Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Gene: MAFB

Molekulargewicht: 36 kDa

Gen-ID: 9935

UniProt: Q9Y5Q3