HNRNPA2B1 Antikörper (N-Term)

Produktnummer ABIN6262328

Produktdetails anti-HNRNPA2B1 Antikörper

Target: HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNRNPA2B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: HnRNP A2/B1 Antibody detects endogenous levels of total hnRNP A2/B1.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human hnRNP A2/B1, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu HNRNPA2B1

Target: HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1))

Andere Bezeichnung: HNRNPA2B1 (HNRNPA2B1 Produkte)

Synonyme: HNRNPA2 antikoerper, HNRNPB1 antikoerper, HNRPA2 antikoerper, HNRPA2B1 antikoerper, HNRPB1 antikoerper, RNPA2 antikoerper, SNRPB1 antikoerper, hnrpa2b1 antikoerper, MGC53135 antikoerper, HNRNPA2B1 antikoerper, hnrnpa2 antikoerper, hnrnpb1 antikoerper, hnrpa2 antikoerper, hnrpb1 antikoerper, rnpa2 antikoerper, snrpb1 antikoerper, 9130414A06Rik antikoerper, Hnrpa2 antikoerper, Hnrpa2b1 antikoerper, hnrnp-A antikoerper, hnRNP antikoerper, heterogeneous nuclear ribonucleoprotein A2/B1 antikoerper, heterogeneous nuclear ribonucleoprotein A2/B1 S homeolog antikoerper, heterogeneous nuclear ribonucleoproteins A2/B1 antikoerper, HNRNPA2B1 antikoerper, hnrnpa2b1.S antikoerper, hnrnpa2b1 antikoerper, Hnrnpa2b1 antikoerper, LOC100353281 antikoerper

Hintergrund:

Description: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).

Gene: HNRNPA2B1

Molekulargewicht: 37kDa

Gen-ID: 3181

UniProt: P22626