Granzyme B/H (N-Term) Antikörper
Kurzübersicht für Granzyme B/H (N-Term) Antikörper (ABIN6262072)
Target
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- N-Term
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Verwendungszweck
- Granzyme B/H Antibody
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Spezifität
- Granzyme B antibody detects endogenous levels of total Granzyme B
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Homologie
- Pig,Bovine,Horse,Dog
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Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
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Immunogen
- A synthesized peptide derived from human Granzyme B/H, corresponding to a region within N-terminal amino acids.
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Isotyp
- IgG
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Applikationshinweise
- WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
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Haltbarkeit
- 12 months
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- Granzyme B/H
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Hintergrund
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Description: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Gene: GZMB
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Molekulargewicht
- 28kDa
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Gen-ID
- 3002
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UniProt
- P10144
Target
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