EYA2 Antikörper (Internal Region)

Produktnummer ABIN6261629

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch EYA2 in WB, ELISA, IF und ICC. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für EYA2 Antikörper (Internal Region) (ABIN6261629)

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-EYA2 Antikörper

Bindungsspezifität: Internal Region

Spezifität: EYA2 Antibody detects endogenous levels of total EYA2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EYA2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu EYA2

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Andere Bezeichnung: EYA2

Hintergrund:

Description: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1 (PubMed:12500905).

Gene: EYA2

Molekulargewicht: 59 kDa

Gen-ID: 2139

UniProt: O00167