EIF3I Antikörper (C-Term)

Produktnummer ABIN6261483

Produktdetails anti-EIF3I Antikörper

Target: EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I (EIF3I))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: EIF3I Antibody detects endogenous levels of total EIF3I.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EIF3I, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu EIF3I

Target: EIF3I (Eukaryotic Translation Initiation Factor 3, Subunit I (EIF3I))

Andere Bezeichnung: EIF3I (EIF3I Produkte)

Synonyme: EIF3S2 antikoerper, PRO2242 antikoerper, TRIP-1 antikoerper, TRIP1 antikoerper, eIF3-beta antikoerper, eIF3-p36 antikoerper, 36kDa antikoerper, D4Ertd632e antikoerper, Eif3s2 antikoerper, Trip1 antikoerper, eIF-3-beta antikoerper, eIF3 p36 antikoerper, eif3s2 antikoerper, hm:zehn0464 antikoerper, wu:fb62b08 antikoerper, zgc:56211 antikoerper, zgc:77823 antikoerper, CaO19.2967 antikoerper, eIF-3 39 kDa subunit homolog antikoerper, eIF3i antikoerper, eif3-beta antikoerper, eif3-p36 antikoerper, eif3i antikoerper, pro2242 antikoerper, trip-1 antikoerper, trip1 antikoerper, eukaryotic translation initiation factor 3 subunit I antikoerper, eukaryotic translation initiation factor 3, subunit I antikoerper, Eukaryotic Initiation Factor antikoerper, Eukaryotic translation initiation factor 3 subunit I antikoerper, translation initiation factor eIF3 subunit i antikoerper, eukaryotic translation initiation factor 3 subunit I L homeolog antikoerper, EIF3I antikoerper, Eif3i antikoerper, eif-3.I antikoerper, eIF3i antikoerper, eif3i antikoerper, TIF34 antikoerper, eif3i.L antikoerper

Hintergrund:

Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene: EIF3I

Molekulargewicht: 36 kDa

Gen-ID: 8668

UniProt: Q13347

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Ribonucleoprotein Complex Subunit Organization, Synthesis of DNA