DOCK7 Antikörper (N-Term)

Produktnummer ABIN6261348

Der Kaninchen Polyklonal Anti-DOCK7-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, DOCK7 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für DOCK7 Antikörper (N-Term) (ABIN6261348)

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK7 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-DOCK7 Antikörper

Bindungsspezifität: N-Term

Spezifität: DOCK7 Antibody detects endogenous levels of total DOCK7.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DOCK7, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu DOCK7

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Andere Bezeichnung: DOCK7

Hintergrund:

Description: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation, negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).

Gene: DOCK7

Molekulargewicht: 242kDa

Gen-ID: 85440

UniProt: Q96N67