CTNNA2 Antikörper (C-Term)

Produktnummer ABIN6261087

Der Kaninchen Polyklonal Anti-CTNNA2-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, CTNNA2 in Proben von Human zu detektieren.

Kurzübersicht für CTNNA2 Antikörper (C-Term) (ABIN6261087)

Target: CTNNA2 (Catenin (Cadherin-Associated Protein), alpha 2 (CTNNA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTNNA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-CTNNA2 Antikörper

Bindungsspezifität: C-Term

Spezifität: CTNNA1/CTNNA2 Antibody detects endogenous levels of total CTNNA1/CTNNA2.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CTNNA1/CTNNA2, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CTNNA2

Target: CTNNA2 (Catenin (Cadherin-Associated Protein), alpha 2 (CTNNA2))

Andere Bezeichnung: CTNNA1,CTNNA2

Hintergrund:

Description: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Gene: CTNNA1

Molekulargewicht: 100kDa

Gen-ID: 1495, 1496

UniProt: P35221, P26232

Pathways: Regulation of Muscle Cell Differentiation