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CHMP2A Antikörper (Internal Region)

Der Kaninchen Polyklonal Anti-CHMP2A-Antikörper wurde für WB, IHC, ICC und IF validiert. Er ist geeignet, CHMP2A in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN6260811

Kurzübersicht für CHMP2A Antikörper (Internal Region) (ABIN6260811)

Target

Alle CHMP2A Antikörper anzeigen
CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Reaktivität

  • 26
  • 20
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 39
  • 2
Kaninchen

Klonalität

  • 41
Polyklonal

Konjugat

  • 11
  • 5
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CHMP2A Antikörper ist unkonjugiert

Applikation

  • 32
  • 16
  • 13
  • 13
  • 9
  • 6
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 15
    • 8
    • 2
    • 2
    • 1
    Internal Region

    Spezifität

    CHMP2A Antibody detects endogenous levels of total CHMP2A.

    Homologie

    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human CHMP2A, corresponding to a region within the internal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

    Andere Bezeichnung

    CHMP2A

    Hintergrund

    Description: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

    Gene: CHMP2A

    Molekulargewicht

    32 kDa

    Gen-ID

    27243

    UniProt

    O43633

    Pathways

    SARS-CoV-2 Protein Interaktom
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