ASPM Antikörper (Internal Region)

Produktnummer ABIN6260082

Der Kaninchen Polyklonal Anti-ASPM-Antikörper wurde für ELISA, IHC, IF, WB und ICC validiert. Er ist geeignet, ASPM in Proben von Human und Ratte zu detektieren.

Kurzübersicht für ASPM Antikörper (Internal Region) (ABIN6260082)

Target: ASPM (Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASPM Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting (WB), Immunocytochemistry (ICC)

Produktdetails anti-ASPM Antikörper

Bindungsspezifität: Internal Region

Spezifität: ASPM Antibody detects endogenous levels of total ASPM.

Homologie: Bovine,Horse,Sheep,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ASPM, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ASPM

Target: ASPM (Asp (Abnormal Spindle) Homolog, Microcephaly Associated (ASPM))

Andere Bezeichnung: ASPM

Hintergrund:

Description: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

Gene: ASPM

Molekulargewicht: 410 kDa

Gen-ID: 259266

UniProt: Q8IZT6