ASIP Antikörper (Internal Region)

Produktnummer ABIN6260077

Dieser Anti-ASIP Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von ASIP in ELISA und WB. Geeignet für Human.

Kurzübersicht für ASIP Antikörper (Internal Region) (ABIN6260077)

Target: ASIP (Agouti Signaling Protein (ASIP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASIP Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-ASIP Antikörper

Bindungsspezifität: Internal Region

Spezifität: ASIP Antibody detects endogenous levels of total ASIP.

Homologie: Bovine,Horse,Sheep,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ASIP, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ASIP

Target: ASIP (Agouti Signaling Protein (ASIP))

Andere Bezeichnung: ASIP

Hintergrund:

Description: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

Gene: ASIP

Molekulargewicht: 14 kDa

Gen-ID: 434

UniProt: P42127

Pathways: Cell-Cell Junction Organization, Feeding Behaviour