APOBEC3C Antikörper

Produktnummer ABIN6259986

Der Kaninchen Polyklonal Anti-APOBEC3C-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, APOBEC3C in Proben von Human und Maus zu detektieren.

Kurzübersicht für APOBEC3C Antikörper (ABIN6259986)

Target: APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOBEC3C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-APOBEC3C Antikörper

Spezifität: APOBEC3C Antibody detects endogenous levels of total APOBEC3C

Kreuzreaktivität: Human, Maus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human APOBEC3C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000 IHC 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu APOBEC3C

Target: APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))

Andere Bezeichnung: APOBEC3C

Hintergrund:

Description: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Gene: APOBEC3C

Molekulargewicht: 23 kDa

Gen-ID: 27350

UniProt: Q9NRW3