ANGPTL4 Antikörper (N-Term)

Produktnummer ABIN6259932

Der Kaninchen Polyklonal Anti-ANGPTL4-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, ANGPTL4 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für ANGPTL4 Antikörper (N-Term) (ABIN6259932)

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANGPTL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-ANGPTL4 Antikörper

Bindungsspezifität: N-Term

Spezifität: ANGPTL4 Antibody detects endogenous levels of total ANGPTL4.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ANGPTL4, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ANGPTL4

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Andere Bezeichnung: ANGPTL4

Hintergrund:

Description: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

Gene: ANGPTL4

Molekulargewicht: 45kDa

Gen-ID: 51129

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha