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AHCYL1 Antikörper (N-Term)

This anti-AHCYL1 antibody (ABIN6259835) is a Rabbit Polyclonal antibody detecting AHCYL1 in WB, IHC. Suitable for Human, Mouse, Rat.
Produktnummer ABIN6259835

Quick Overview for AHCYL1 Antikörper (N-Term) (ABIN6259835)

Target

Alle AHCYL1 Antikörper anzeigen
AHCYL1 (Adenosylhomocysteinase-Like 1 (AHCYL1))

Reaktivität

  • 19
  • 12
  • 12
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 16
  • 3
Kaninchen

Klonalität

  • 17
  • 2
Polyklonal

Konjugat

  • 19
Dieser AHCYL1 Antikörper ist unkonjugiert

Applikation

  • 17
  • 9
  • 7
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    N-Term

    Spezifität

    AHCYL1 Antibody detects endogenous levels of total AHCYL1.

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human AHCYL1, corresponding to a region within N-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:50-1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    AHCYL1 (Adenosylhomocysteinase-Like 1 (AHCYL1))

    Andere Bezeichnung

    AHCYL1

    Hintergrund

    Description: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3- and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3- secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).

    Gene: AHCYL1

    Molekulargewicht

    60 kDa

    Gen-ID

    10768

    UniProt

    O43865
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