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AGRN Antikörper (C-Term)

Dieses Rabbit Polyclonal-Antikörper erkennt spezifisch AGRN in WB, ELISA, ICC, IF. Er zeigt eine Reaktivität gegenüber Human, Rat, Mouse.
Produktnummer ABIN6259829

Kurzübersicht für AGRN Antikörper (C-Term) (ABIN6259829)

Target

Alle AGRN Antikörper anzeigen
AGRN (Agrin (AGRN))

Reaktivität

Human, Ratte, Maus

Wirt

  • 26
  • 4
Kaninchen

Klonalität

  • 26
  • 4
Polyklonal

Konjugat

  • 20
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AGRN Antikörper ist unkonjugiert

Applikation

  • 18
  • 15
  • 11
  • 10
  • 9
  • 4
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    AGRN Antibody detects endogenous levels of total AGRN.

    Homologie

    Pig,Zebrafish,Bovine,Dog,Chicken

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human AGRN, corresponding to a region within C-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20 °C. Stable for 12 months from date of receipt.

    Haltbarkeit

    12 months
  • Target

    AGRN (Agrin (AGRN))

    Andere Bezeichnung

    AGRN

    Hintergrund

    Description: Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha3-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.

    Gene: AGRN

    Molekulargewicht

    217kDa

    Gen-ID

    375790

    UniProt

    O00468

    Pathways

    Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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