AFF4 Antikörper (C-Term)
Kurzübersicht für AFF4 Antikörper (C-Term) (ABIN6259815)
Target
Alle AFF4 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- C-Term
-
Spezifität
- AFF4 Antibody detects endogenous levels of total AFF4.
-
Homologie
- Pig,Bovine,Horse,Sheep,Chicken
-
Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
Immunogen
- A synthesized peptide derived from human AFF4, corresponding to a region within C-terminal amino acids.
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 1 mg/mL
-
Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
-
Haltbarkeit
- 12 months
-
-
- AFF4 (AF4/FMR2 Family, Member 4 (AFF4))
-
Andere Bezeichnung
- AFF4
-
Hintergrund
-
Description: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
Gene: AFF4
-
Molekulargewicht
- 127kDa
-
Gen-ID
- 27125
-
UniProt
- Q9UHB7
Target
-