TADA2L Antikörper

Produktnummer ABIN6259764

Der Kaninchen Polyklonal Anti-TADA2L-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, TADA2L in Proben von Human, Maus, Ratte und Affe zu detektieren.

Kurzübersicht für TADA2L Antikörper (ABIN6259764)

Target: TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TADA2L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-TADA2L Antikörper

Spezifität: ADA2L antibody detects endogenous levels of total ADA2L

Kreuzreaktivität: Human, Affe, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ADA2L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500~1:3000, IF/ICC 1:100-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu TADA2L

Target: TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))

Andere Bezeichnung: ADA2L

Hintergrund:

Description: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).

Gene: TADA2A

Molekulargewicht: 47kDa

Gen-ID: 6871

UniProt: O75478

Pathways: Chromatin Binding