ACIN1 Antikörper

Produktnummer ABIN6259729

Produktdetails anti-ACIN1 Antikörper

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACIN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: ACINU Antibody detects endogenous levels of total ACINU

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ACINU

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu ACIN1

Target: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Andere Bezeichnung: ACINU (ACIN1 Produkte)

Synonyme: acinus antikoerper, acinusb antikoerper, fi14c05 antikoerper, wu:fe06a10 antikoerper, wu:fi14c05 antikoerper, acinusa antikoerper, acinusl antikoerper, ik:tdsubc_2g5 antikoerper, si:zc14a17.12 antikoerper, wu:fb04g06 antikoerper, wu:fb40f03 antikoerper, wu:fb68h03 antikoerper, wu:fb80f07 antikoerper, wu:fc12e10 antikoerper, xx:tdsubc_2g5 antikoerper, acn antikoerper, ACINUS antikoerper, ACN antikoerper, fSAP152 antikoerper, 2610036I19Rik antikoerper, 2610510L13Rik antikoerper, Acinus antikoerper, Acn antikoerper, C79325 antikoerper, acinusL antikoerper, acinusS antikoerper, mKIAA0670 antikoerper, apoptotic chromatin condensation inducer 1b antikoerper, apoptotic chromatin condensation inducer 1a antikoerper, apoptotic chromatin condensation inducer 1 antikoerper, apoptotic chromatin condensation inducer 1 S homeolog antikoerper, acin1b antikoerper, acin1a antikoerper, acin1 antikoerper, ACIN1 antikoerper, acin1.S antikoerper, Acin1 antikoerper

Hintergrund:

Description: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets, ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

Gene: ACIN1

Molekulargewicht: 152 kDa

Gen-ID: 22985

UniProt: Q9UKV3