Manic Fringe Antikörper (Internal Region)
Kurzübersicht für Manic Fringe Antikörper (Internal Region) (ABIN6258883)
Target
Alle Manic Fringe (MFNG) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
- 
    - 
                                            Bindungsspezifität
- Internal Region
- 
                                            Spezifität
- MFNG Antibody detects endogenous levels of total MFNG.
- 
                                            Homologie
- Pig,Bovine,Horse,Dog
- 
                                            Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 
                                            Immunogen
- A synthesized peptide derived from human MFNG, corresponding to a region within the internal amino acids.
- 
                                            Isotyp
- IgG
 
- 
                                            
- 
    
- 
    - 
                                            Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 
                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
- 
                                            
- 
    - 
                                            Format
- Liquid
- 
                                            Konzentration
- 1 mg/mL
- 
                                            Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 
                                            Konservierungsmittel
- Sodium azide
- 
                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 
                                            Lagerung
- -20 °C
- 
                                            Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- 
                                            Haltbarkeit
- 12 months
 
- 
                                            
- 
    - Manic Fringe (MFNG) (MFNG)
- 
                                            Andere Bezeichnung
- MFNG
- 
                                            Hintergrund
- 
                        Description: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Gene: MFNG 
- 
                                            Molekulargewicht
- 38 kDa
- 
                                            Gen-ID
- 4242
- 
                                            UniProt
- O00587
- 
                                            Pathways
- Notch Signalweg
 Target
- 
                    
 
                                     
                                     
                                    