BCL11B Antikörper (Internal Region)

Produktnummer ABIN6258605

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BCL11B in WB, ELISA, IHC, IF und ICC. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für BCL11B Antikörper (Internal Region) (ABIN6258605)

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL11B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-BCL11B Antikörper

Bindungsspezifität: Internal Region

Spezifität: BCL11B Antibody detects endogenous levels of total BCL11B.

Homologie: Pig,Bovine,Sheep,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BCL11B, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu BCL11B

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Andere Bezeichnung: BCL11B

Hintergrund:

Description: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).

Gene: BCL11B

Molekulargewicht: ?95 kDa

Gen-ID: 64919

UniProt: Q9C0K0