GNA13 Antikörper (N-Term)

Produktnummer ABIN6257750

Produktdetails anti-GNA13 Antikörper

Target: GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNA13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: GNA13 Antibody detects endogenous levels of total GNA13.

Homologie: Pig,Rabbit,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GNA13, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu GNA13

Target: GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))

Andere Bezeichnung: GNA13 (GNA13 Produkte)

Synonyme: Galpha13 antikoerper, gna13 antikoerper, wu:fe25e05 antikoerper, zgc:112436 antikoerper, Gna13 antikoerper, fj64c01 antikoerper, wu:fj64c01 antikoerper, GNA13 antikoerper, G13 antikoerper, AU024132 antikoerper, AU043124 antikoerper, G protein subunit alpha 13 antikoerper, guanine nucleotide binding protein (G protein), alpha 13a antikoerper, guanine nucleotide binding protein (G protein), alpha 13b antikoerper, guanine nucleotide binding protein, alpha 13 antikoerper, Gna13 antikoerper, gna13a antikoerper, gna13b antikoerper, GNA13 antikoerper

Hintergrund:

Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Gene: GNA13

Molekulargewicht: 44 kDa

Gen-ID: 10672

UniProt: Q14344

Pathways: CXCR4-mediated Signaling Events