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Sorting Nexin 1 Antikörper (Internal Region)

SNX1 Reaktivität: Human, Ratte, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257498
  • Target Alle Sorting Nexin 1 (SNX1) Antikörper anzeigen
    Sorting Nexin 1 (SNX1)
    Bindungsspezifität
    • 15
    • 12
    • 8
    • 6
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 59
    • 39
    • 21
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 68
    • 5
    • 3
    • 1
    Kaninchen
    Klonalität
    • 65
    • 12
    Polyklonal
    Konjugat
    • 32
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sorting Nexin 1 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 30
    • 14
    • 14
    • 12
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    SNX1 Antibody detects endogenous levels of total SNX1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SNX1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SNX1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    Sorting Nexin 1 (SNX1)
    Andere Bezeichnung
    SNX1 (SNX1 Produkte)
    Synonyme
    d254 antikoerper, sb:cb923 antikoerper, snx1 antikoerper, wu:fb40c08 antikoerper, wu:fj65g09 antikoerper, MGC82200 antikoerper, SNX1 antikoerper, HsT17379 antikoerper, VPS5 antikoerper, ARABIDOPSIS THALIANA SORTING NEXIN 1 antikoerper, ATSNX1 antikoerper, K16F4.11 antikoerper, K16F4_11 antikoerper, sorting nexin 1 antikoerper, sorting nexin 1a antikoerper, sorting nexin 1 L homeolog antikoerper, sorting nexin 1 antikoerper, sorting nexin-1 antikoerper, snx1a antikoerper, snx1.L antikoerper, SNX1 antikoerper, snx1 antikoerper, LOC100380673 antikoerper, Snx1 antikoerper
    Hintergrund

    Description: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

    Gene: SNX1

    Molekulargewicht
    59 kDa
    Gen-ID
    6642
    UniProt
    Q13596
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