Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CSNK2A2 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-CSNK2A2-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, CSNK2A2 in Proben von Human und Maus zu detektieren.
Produktnummer ABIN6257088

Kurzübersicht für CSNK2A2 Antikörper (N-Term) (ABIN6257088)

Target

Alle CSNK2A2 Antikörper anzeigen
CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))

Reaktivität

  • 40
  • 23
  • 13
  • 5
  • 5
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human, Maus

Wirt

  • 37
  • 3
Kaninchen

Klonalität

  • 37
  • 3
Polyklonal

Konjugat

  • 21
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CSNK2A2 Antikörper ist unkonjugiert

Applikation

  • 25
  • 22
  • 11
  • 8
  • 5
  • 2
  • 2
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Spezifität

    CSNK2A2 Antibody detects endogenous levels of total CSNK2A2.

    Homologie

    Pig,Bovine,Chicken,Xenopus

    Aufreinigung

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    Immunogen

    A synthesized peptide derived from human CSNK2A2, corresponding to a region within N-terminal amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Haltbarkeit

    12 months
  • Target

    CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))

    Andere Bezeichnung

    CSNK2A2

    Hintergrund

    Description: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

    Gene: CSNK2A2

    Molekulargewicht

    41 kDa

    Gen-ID

    1459

    UniProt

    P19784

    Pathways

    SARS-CoV-2 Protein Interaktom
Sie sind hier:
Chat with us!