Crk Antikörper (pTyr221)
Kurzübersicht für Crk Antikörper (pTyr221) (ABIN6256674)
Target
Alle Crk (CRK) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pTyr221
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Spezifität
- Phospho-CrkII (Tyr221) Antibody detects endogenous levels of CrkII only when phosphorylated at Tyrosine 221
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Kreuzreaktivität
- Human, Affe, Maus, Ratte (Rattus)
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Aufreinigung
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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Immunogen
- A synthesized peptide derived from human CrkII around the phosphorylation site of Tyrosine 221
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Isotyp
- IgG
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Applikationshinweise
- WB 1:500-1:2000 IF/ICC 1:100-1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
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Haltbarkeit
- 12 months
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- Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))
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Andere Bezeichnung
- CrkII
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Hintergrund
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Description: Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Gene: CRK
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Molekulargewicht
- 42kDa
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Gen-ID
- 1398
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UniProt
- P46108
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Pathways
- Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
Target
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