RanBP3 Antikörper (pSer58, pSer126)

Produktnummer ABIN6256379

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch RanBP3 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für RanBP3 Antikörper (pSer58, pSer126) (ABIN6256379)

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RanBP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-RanBP3 Antikörper

Bindungsspezifität: pSer58, pSer126

Spezifität: Phospho-RanBP3 (Ser126/58) Antibody detects endogenous levels of RanBP3.

Kreuzreaktivität: Human, Maus

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human RanBP3 around the phosphorylation site of Ser126/58.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Details zu RanBP3

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Andere Bezeichnung: RanBP3

Hintergrund:

Description: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene: RANBP3

Molekulargewicht: 70kDa

Gen-ID: 8498

UniProt: Q9H6Z4