Histone H3.1 Antikörper (pSer10)

Produktnummer ABIN6254919

Der Kaninchen Polyklonal Anti-Histone H3.1-Antikörper wurde für WB, IHC, IF, ELISA und ICC validiert. Er ist geeignet, Histone H3.1 in Proben von Human, Maus und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Histone H3.1 Antikörper (pSer10) (ABIN6254919)

Target: Histone H3.1 (HIST1H3B)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Histone H3.1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-Histone H3.1 Antikörper

Bindungsspezifität: pSer10

Spezifität: Phospho-Histone H3.1 (Ser10) Antibody detects endogenous levels of Histone H3.1 only when phosphorylated at Serine 10

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human Histone H3.1 around the phosphorylation site of Serine 10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.Stable for 12 months from date of receipt

Haltbarkeit: 12 months

Referenzen für anti-Histone H3.1 Antikörper (ABIN6254919)

Liang, Sun, Zhao, Zhang, Gu, Dong, Zhang, Sun, Sun: "Rictor regulates the vasculogenic mimicry of melanoma via the AKT-MMP-2/9 pathway." in: Journal of cellular and molecular medicine, Vol. 21, Issue 12, pp. 3579-3591, (2018) (PubMed).

Wu, Wang, Yang, Huang, Hu, Shu, Zhang, Zheng: "MAD2-p31comet axis deficiency reduces cell proliferation, migration and sensitivity of microtubule-interfering agents in glioma." in: Biochemical and biophysical research communications, Vol. 498, Issue 1, pp. 157-163, (2018) (PubMed).

Details zu Histone H3.1

Target: Histone H3.1 (HIST1H3B)

Andere Bezeichnung: Histone H3.1

Hintergrund:

Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene: HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Molekulargewicht: 17kDa

Gen-ID: 8, 350, 835

UniProt: P68431, Q71DI3, P84243