NOTCH2 Antikörper
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- Target Alle NOTCH2 Antikörper anzeigen
- NOTCH2 (Notch 2 (NOTCH2))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NOTCH2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Cleaved-Notch2 (Asp1733) Antibody detects endogenous levels of fragment of activated Notch2 resulting from cleavage adjacent to Asp1733.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NOTCH2 (UniProt Q04721), corresponding to amino acid residues L1717-S1741.
- Isotyp
- IgG
- Top Product
- Discover our top product NOTCH2 Primärantikörper
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anti-Notch 2 (NOTCH2) antibody
NOTCH2 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Asp1733), (cleaved) antibodyNOTCH2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (C-Term) antibodyNOTCH2 Reaktivität: Human, Maus WB, ChIP-seq Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Asp1733) antibodyNOTCH2 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 59-250) antibodyNOTCH2 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2251-2466) antibodyNOTCH2 Reaktivität: Human WB, ELISA, IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 1501-1700) antibodyNOTCH2 Reaktivität: Human, Maus WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (AA 2242-2471) antibodyNOTCH2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Ala1734) antibodyNOTCH2 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Notch 2 (NOTCH2) (Cleaved-Ala1734), (Internal Region) antibodyNOTCH2 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- NOTCH2 (Notch 2 (NOTCH2))
- Andere Bezeichnung
- NOTCH2 (NOTCH2 Produkte)
- Hintergrund
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Description: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Gene: NOTCH2
- Molekulargewicht
- 110 kDa
- Gen-ID
- 4853
- UniProt
- Q04721
- Pathways
- Notch Signalweg, Stem Cell Maintenance
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