CD4 Antikörper

Produktnummer ABIN6254232

Zitiert in 1 Publikation. Der Ziege Polyklonal anti-CD4 Antikörper (ABIN6254232) detektiert spezifisch CD4 in WB, IHC (fro) und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Huhn, Affe, Hund, Schwein, Kaninchen, Rind (Kuh), Schaf, Meerschweinchen, Ziege, Pferd, Avian, Esel und Hamster.

Kurzübersicht für CD4 Antikörper (ABIN6254232)

Highlights:

• High quality CD4 Primärantikörper for the detection of CD4.
• Reliable product with high standard validation data

Target: CD4

Reaktivität: Human, Maus, Ratte, Huhn, Affe, Hund, Schwein, Kaninchen, Rind (Kuh), Schaf, Meerschweinchen, Ziege, Pferd, Avian, Esel, Hamster

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CD4 Antikörper

Verwendungszweck: Anti-CD4

Sequenz: FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS KLTGSG

Spezifität: Using spleen lysate detects a 52 kDa band by Western blot.

Produktmerkmale: CD4 Molecule

Aufreinigung: Epitope affinity purified

Immunogen: Purified recombinant peptide derived from within 50 to 235 aa, corresponding to the external domain of human CD4 produced in E. coli.

Isotyp: IgG

Produktspezifische Information:

What can the CD4 Antibody ABIN6254232 be used for?: This polyclonal CD4 Antibody detects CD4. The CD4 Antibody has been validated for various applications and can be used for the detection of CD4 and derivatives by Western Blotting, Immunohistochemistry (Frozen Sections), Immunohistochemistry (Paraffin-embedded Sections).

What validation data is available for this CD4 Antibody?: The Primärantikörper is referenced in 1 publications and is characterized by a proven, very high reliability. It has currently 6 product images that show its performance in a variety of applications. The product is currently available in 600 μg quantity. CD4 Antibody for the detection of CD4 and derivatives.

What is the function of CD4?: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010].

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:2,000, IHC-P:1:250-1:1,000, IHC-F:1:250-1:1,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 20 % glycerol and 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody solution should be gently mixed before use.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For continuous use, store at 2-8 C for one-two days. For extended storage, store in -20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Referenzen für anti-CD4 Antikörper (ABIN6254232)

Helsby, Leader, Fenn, Gulsen, Bryant, Doughton, Sharpe, Whitley, Caunt, James, Pope, Kelly, Chalmers: "CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited." in: BMC cell biology, Vol. 15, pp. 6, (2014) (PubMed).

Details zu CD4

Target: CD4

Andere Bezeichnung: CD4

Hintergrund:

Goat polyclonal antibody to CD4. CD4 is a member of the immunoglobulin superfamily, a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and a receptor for the human immunodeficiency virus. This protein is expressed not only on the surface of T helper cells and regulatory T cells but also on monocytes, macrophages and dendritic cells. It functions to initiate or amplify the early phase of T-cell activation and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.

CD4mut, CD4 antigen (p55), CD4 Receptor, T-cell surface antigen T4/Leu-3 and T-cell surface glycoprotein CD4 antibody.

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events