CD16 Antikörper

Produktnummer ABIN6253847

Dieses Anti-CD16-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD16 in FACS und ICC. Geeignet für Human.

Kurzübersicht für CD16 Antikörper (ABIN6253847)

Target: CD16

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD16 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: B-E16

Produktdetails anti-CD16 Antikörper

Spezifität: B-E16 produces mouse IgG2a immunoglobulins specific for a 50-70 kD antigen which is associated with the IgG FceRI on NK cells, neutrophils, granulocytes and monocytes [3]

Reinheit: PURE

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: immunohistochemistry on cytospots,  immunohistochemistry on frozen tissue

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C

Details zu CD16

Target: CD16

Andere Bezeichnung: CD16

Hintergrund: Antigen distribution: CD16 is a low-affinity receptor for aggregated IgG (FcgRIII) [1,2]. The transmembrane form of CD16 is expressed on approximately 15% of peripheral blood lymphocytes and is present on virtually all resting NK cells. It is also found on macrophages and mast cells. It binds IgG complexed to antigens and mediates phagocytosis and antibody-dependent cellular cytotoxicity. On NK cells it mediates signal transduction while the GPI-linked form on neutrophils binds to ligands but is unable to induce any signal or functional effect [1]. Cellular Expression: NK cells, neutrophils, granulocytes, macrophages.

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process