Rekombinanter DLG4 Antikörper

Produktnummer ABIN6253485

Der Human Monoklonal Anti-DLG4-Antikörper wurde für IHC und ICC validiert. Er ist geeignet, DLG4 in Proben von Ratte, Human und Maus zu detektieren.

Kurzübersicht für Rekombinanter DLG4 Antikörper (ABIN6253485)

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Ratte, Human, Maus

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser DLG4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: PF11

Produktdetails anti-DLG4 Antikörper

Verwendungszweck: anti-PSD-95 (palmitoylated), mAb (rec.) (PF11)

Produktmerkmale: Recombinant Antibody. Recognizes human, mouse and rat palmitoylated PSD-95. Isotype: Human IgG2. Clone: PF11. Applications: ICC, IHC. Liquid. In PBS containing 10 % glycerol. PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Palmitoylated PSD-95.

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. In PBS containing 10 % glycerol.

Handhabung: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

Details zu DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Andere Bezeichnung: PSD-95

Hintergrund:

Alternate Names/Synonyms: PSD95, Disks Large Homolog 4, DLG4, Postsynaptic Density Protein 95, Synapse-associated Protein 90, SAP90

Product Description: PSD-95 is a member of proteins located at a specialized postsynaptic membrane region, called the postsynaptic density (PSD). PSD-95 is the most abundant scaffold protein specifically enriched in the PSD. It contains three PDZ domains, an SH3 domain and a guanylate kinase (GuK)-like domain. Through its PDZ domains, PSD-95 assembles various synaptic components at the PSD including intracellular signaling molecules (e.g. SynGAP and kalirin-7), ion channels (e.g. stargazin/AMPA receptors [AMPARs] and NMDA receptors) and cell adhesion molecules (e.g. neuroligin). PSD-95 plays a primary role in synaptic development and maturation and is regulated by palmitoylation at its N-terminal cysteine residues leading to its postsynaptic targeting. Palmitoylation of PSD-95 is triggered by DHHC2, a plasma membrane-inserted palmitoylating enzyme. Palmitoylated PSD-95 is almost exclusively localized at excitatory synapses in neurons.

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity