GP2 Antikörper (AA 35-179)

Produktnummer ABIN6252885

Dieser Maus Monoklonal Antikörper detektiert spezifisch GP2 in IHC (p), FACS und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für GP2 Antikörper (AA 35-179) (ABIN6252885)

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GP2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: GP2-1712

Produktdetails anti-GP2 Antikörper

Bindungsspezifität: AA 35-179

Spezifität: Does not react with Mouse

Aufreinigung: Protein G affinity chromatography

Immunogen: A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.

Isotyp: IgG2b lambda

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 0.5-1 μg/10e6 cells in 0.1ml

Immunofluorescence: 0.5-1 μg/mL

IHC (FFPE): 1-2 μg/mL for 30 min at RT

Optimal dilution of the GP2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Details zu GP2

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Andere Bezeichnung: Glycoprotein 2

Hintergrund: GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Gen-ID: 2813

UniProt: P55259